What was the GP looking for in the patient,s general appearance?
Info:
Cushing's Disease:
is caused by excess glucocorticoid production, usually from a pituitary tumour producing ACTH. Exogenous steroid intake, ectopic ACTH or an adrenal tumour may produce the same clinical phenotype.
Signs/ Symptoms of Cushing's Disease include central obesity, plethoric moon face, buffalo hump, violaceous striae, thin skin, easy bruising, hirsuitism, osteoporosis, amenorrhoea, proximal myopathy, hypertension, diabetes, and dyslipidaemia. Hypertension is a very common co-morbidity in patients with Cushing's Disease/Syndrome, resulting from the interplay of several pathophysiological mechanisms, including stimulation of mineralocorticoid and glucocorticoid receptors as well as the associated insulin resistance, sleep apnoea and activation of the renin-angiotensin system. Although treatment of Cushing's Disease/Syndrome resolves or ameliorates hypertension, a significant proportion of patients do not achieve complete cure or require a prolonged period of time for complete response to therapy.
Acromegaly:
Acromegaly is caused by excess growth hormone production from a pituitary tumour.
Symptoms of Acromegaly include:
Sweating, headache, visual disturbance, swollen hands and feet, bone overgrowth, coarse skin, enlarged tongue, sleep apnoea, snoring, carpal tunnel syndrome, hypertension, myopathy, menstrual disturbance.
Obesity:
Obesity is the fastest growing cause of hypertension. The exact cause of obesity associated hypertension is unclear but it may be linked to abnormal adipokine production (chemical messengers from fat tissue) or secondary to sleep apnoea.